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#Cancer Cells are susceptible to damage by pathogens, mutations, and free radicals. Some of the most common causes of cell damage are radiation therapy treatment for cancer patients, poor diet (including inadequate intake of antioxidants), smoking, infection with human papillomavirus (HPV) which causes cervical cancer in women and genital warts in men or women, and exposure to certain chemicals such as pesticides. In some cases the cause is unknown. In general though cellular damage can lead to a host of symptoms from minor problems such as allergies to serious diseases such as leukemia. The best way to prevent cellular damage is to minimize our exposure to harmful agents. The front line of defense against those agents is the cell's ability to repair damage done by them and inhibit their further growth and spread. The first and most obvious sign that cellular damage has occurred is a symptom. Signs of cell damage include:

Although risks can be minimized with proper diet and avoidance of harmful lifestyles, there are certain risks we cannot avoid. For example, we know that x-rays cause cancer, but since they are so short-lived (1/30th of a second) it may only take one lifetime of exposure to x-rays for someone to develop cancer later in life. In addition, there are also some cancers that cannot be prevented by lifestyle choice. For example, there is a way to detect the disease in the early stages and treat it with surgery and chemotherapy, but this method will not work for everyone. As a result cancer is a disease for which we have very little control over one's chances of developing after exposure to a death-causing agent. Cells have the ability to develop defenses against damage from various agents. These mechanisms include:

In order to minimize damage from cancer, scientists have been looking for ways to boost cellular defenses against cells. This has been done by utilizing certain naturally occurring compounds that increase resistance against cancer in test tubes and in lab animals.

The paper "Endothelial cell growth and angiogenesis stimulated by novel polyketides from marine sponges" describes the effects of a marine compound extracted from the sponge "Alphamembranous columella" on endothelial cells. This study demonstrated that extracts of this sponge have potent anti-angiogenic effects on both in vitro and ex vivo conditions. Researchers have reported that anticancer drugs are usually toxic to healthy tissues, so they try to minimize the dose while maximizing the cancer cell death. This is currently accomplished by using mice that have human prostate cancer that are implanted with an antibiotic-resistent gene. The paper "Combination pharmacologic inhibition of class I histone deacetylases and HDAC2 in cancer cells" reports the suppression of tumor growth in mice by administering the HDAC inhibitors sodium butyrate and trichostatin A. The authors conclude by saying, "Induction of apoptosis was associated with G2 cell cycle arrest, suggesting that HDACi might be useful in combination with other anti-cancer agents to treat cancers".

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